Considering the increase of respiratory viruses activity at pre-pandemic levels, and associated hospitalizations predominantly among children under 2 years old age, in the Andean sub region and Southern cone, the Pan American Health Organization / World Health Organization (PAHO/WHO) recommends Member States to strengthen and integrate surveillance for influenza, respiratory syncytial virus (RSV) and SARS-CoV-2 and to adopt the necessary measures for prevention and control of severe outcomes, including the ensuring of high vaccination coverage in at high-risk groups, appropriate clinical management, suitable organization of health care services, strict compliance with infection prevention control measures, adequate supplies of antivirals, and timely treatment of associated complications.